Almac Discovery publishes USP7 inhibitors from UbiPlexTM Platform
Craigavon, N.I., UK, 4 December 2017 – Almac Discovery, a biopharmaceutical company focused on discovering and identifying innovative therapeutics for the treatment of cancer, has today published its findings on the discovery and characterisation of highly potent, selective and reversible inhibitors of ubiquitin-specific protease 7 (USP7) in the journal Nature Chemical Biology. Despite substantial efforts over nearly two decades, the development of validated deubiquitinase (DUB) inhibitors that exhibit drug like properties and a well-defined mechanism has proven particularly challenging—overall, Almac’s findings successfully demonstrate the tractability and druggability of DUBs, and provide important tools for additional target validation studies.


